Second-Chance Signal Transduction Explains Cooperative Flagellar Switching

Second-Chance Signal Transduction Explains Cooperative Flagellar Switching

The reversal of flagellar motion (switching) results from the interaction between a switch complex of the flagellar rotor and a torque-generating stationary unit, or stator (motor unit). To explain the steeply cooperative ligand-induced switching, present models propose allosteric interactions between subunits of the rotor, but do not address the possibility of a reaction that stimulates a bidi...

Intrinsic disorder mediates cooperative signal transduction in STIM1.

Intrinsically disordered domains have been reported to play important roles in signal transduction networks by introducing cooperativity into protein-protein interactions. Unlike intrinsically disordered domains that become ordered upon binding, the EF-SAM domain in the stromal interaction molecule (STIM) 1 is distinct in that it is ordered in the monomeric state and partially unfolded in its o...

Second - chance offers

We study the second-price offer feature of eBay auctions in which the seller has multiple units. Perhaps surprisingly, the opportunity to make second-chance offers can reduce seller profit. This happens if her marginal cost function is sufficiently steep. Hence, sellers should be wary about the possibility that buyers anticipate second-chance offers, and it may be advantageous for a seller to a...

A Regulatory Checkpoint during Flagellar Biogenesis in Campylobacter jejuni Initiates Signal Transduction To Activate Transcription of Flagellar Genes

UNLABELLED Many polarly flagellated bacteria require similar two-component regulatory systems (TCSs) and σ(54) to activate transcription of genes essential for flagellar motility. Herein, we discovered that in addition to the flagellar type III secretion system (T3SS), the Campylobacter jejuni flagellar MS ring and rotor are required to activate the FlgSR TCS. Mutants lacking the FliF MS ring a...

Transduction of flagellar characters in Salmonella.